Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
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DOI：
10.1073/pnas.192314199
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发表时间：
2002-10-01
影响因子：
11.1
通讯作者：
Baron-Van Evercooren, A
中科院分区：
文献类型：
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作者：
Picard-Riera, N;Decker, L;Baron-Van Evercooren, A
成年啮齿动物脑室下区（SVZ）有丝分裂活跃细胞的命运是迁移到嗅球，在那里它们有助于颗粒和肾小球周围神经元的替代。然而，这些成年神经祖细胞也可以动员在脑室周围的白色物质和触发分化成星形胶质细胞和少突胶质细胞响应溶血卵磷脂诱导的脱髓鞘。为了模拟多发性硬化的环境条件，我们评估了成年SVZ祖细胞对小鼠实验性自身免疫性脑脊髓炎（EAE）的增殖、迁移和分化潜力。在EAE诱导后，在所有小鼠脑中观察到炎症和脱髓鞘。EAE诱导整个脑，特别是病变内的细胞增殖。分化细胞为神经祖细胞、星形胶质细胞和少突胶质细胞前体。EAE增强了SVZ源性神经祖细胞向嗅球的迁移，并触发了它们在脑室周围白色物质中的动员。动员的细胞在嗅球中产生神经元、星形胶质细胞和少突胶质细胞，但在受损的白色物质中主要是星形胶质细胞和少突胶质细胞。我们的数据表明，成年小鼠SVZ是一个新产生的少突胶质细胞的来源，因此可能有助于，沿着少突胶质细胞前体，以取代少突胶质细胞的中枢神经系统的炎性脱髓鞘疾病，如多发性硬化症。
The destiny of the mitotically active cells of the subventricular zone (SVZ) in adult rodents is to migrate to the olfactory bulb, where they contribute to the replacement of granular and periglomerular neurons. However, these adult neural progenitors also can be mobilized in periventricular white matter and triggered to differentiate into astrocytes and oligodendrocytes in response to lysolecithin-induced demyelination. To mimic the environmental conditions of multiple sclerosis, we assessed the proliferation, migration, and differentiation potential of adult SVZ progenitor cells in response to experimental autoimmune encephalomyelitis (EAE) in mice. Inflammation and demyelination were observed in all mouse brains after EAE induction. EAE induced cell proliferation throughout the brain and especially within the lesions. Proliferating cells were neural progenitors, astrocytes, and oligodendrocyte precursors. EAE enhanced the migration of SVZ-derived neural progenitors to the olfactory bulb and triggered their mobilization in the periventricular white matter. The mobilized cells gave rise to neurons, astrocytes, and oligodendrocytes in the olfactory bulb but essentially to astrocytes and oligodendrocytes in the lesioned white matter. Our data indicate that the adult mouse SVZ is a source of newly generated oligodendrocytes and thus may contribute, along with oligodendrocyte precursors, to the replacement of oligodendrocytes in inflammatory demyelinating diseases of the central nervous system such as multiple sclerosis.