Toll-like receptor 10 expression in B cells is negatively correlated with the progression of primary Sjogren's disease
Toll-like receptor 10 expression in B cells is negatively correlated with the progression of primary Sjogren's disease
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DOI：
10.1016/j.clim.2022.108989
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发表时间：
2022-04-06
影响因子：
8.6
通讯作者：
Huang, Bihui
中科院分区：
文献类型：
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作者：
Lai, Nannan;Qian, YiChao;Huang, Bihui
原发性干燥病（pSjD）被认为是B细胞介导的疾病。Toll样受体10（TLR10）在人B细胞中高度表达，表明TLR10可能在pSjD中起重要作用。我们检测了pSjD患者外周B亚群中TLR 10的表达，并分析了其与疾病活动性的相关性。我们观察到，与健康对照组和高活性患者相比，低活性pSjD患者的总细胞、初始细胞、记忆细胞和转换记忆B细胞中的TLR 10表达显著增加。TLR10在上述B亚群（除幼稚B）中的表达分别与血清抗SSA抗体和BAFF水平呈负相关。此外，在TLR10低表达患者中观察到高活性pSjD患者的比例高于高表达患者。结论：TLR 10在CD 19（+）B和记忆B中的表达与pSjD疾病活动性呈负相关，提示TLR 10可能参与了pSjD的进展。
Primary Sjogren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity. We observed that TLR10 expression in total, naive, memory, and switched memory B cells was significantly increased in low-activity pSjD patients as compared with healthy controls and high-activity patients. TLR10 expression in the above mentioned B subsets (except naive B) was negatively correlated with serum levels of anti-SSA antibody and BAFF, respectively. Moreover, a higher proportion of high-activity pSjD patients was observed in TLR10 low- than high-expressed patients. Our study concluded that TLR10 expression in CD19(+) B and memory B was negatively correlated with pSjD disease activity, suggesting that TLR10 might take part in the progression of pSjD.