EFFECT OF HISTAMINE H2-RECEPTOR ANTAGONISTS ON DELAYED HYPERSENSITIVITY
EFFECT OF HISTAMINE H2-RECEPTOR ANTAGONISTS ON DELAYED HYPERSENSITIVITY
复制标题
组胺 H2 受体拮抗剂对迟发性超敏反应的影响
DOI：
10.1016/s0140-6736(78)91134-0
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
P. Askenase
中科院分区：
文献类型：
--
作者：
J. Avella;H. Binder;J. Madsen;P. Askenase
在患有尿道溃疡病的患者中，在西咪替丁治疗6周之前和之后评估对四种抗原的延迟皮肤试验应答。在接受西咪替丁治疗的8名患者中，在接受西咪替丁治疗6周后，红斑和硬结均显著增加。相比之下，在6周的迟发性超敏反应的强度没有增加，在8名对照患者谁没有收到西咪替丁。这些研究表明，H2受体拮抗剂治疗可能与迟发型超敏反应的增强有关。
The delayed skin-test response to four antigens was assessed before and after 6 weeks' cimetidine therapy in patients with duodenal-ulcer disease. In the eight patients who received cimetidine there was a significant increase in both erythema and induration after six weeks' cimetidine therapy. In contrast, the intensity of delayed-hypersensitivity reactions at 6 weeks was not increased in eight control patients who did not receive cimetidine. These studies indicate that therapy with an H2-receptor antagonist may be associated with an augmentation of delayed hypersensitivity responses.