Reactivity of anti-Blomia tropicalis IgG and IgE in patients with atopic dermatitis.
Reactivity of anti-Blomia tropicalis IgG and IgE in patients with atopic dermatitis.
复制标题
特应性皮炎患者抗热带布洛米亚 IgG 和 IgE 的反应性。
DOI：
10.1046/j.1365-2230.2002.01029.x
复制
发表时间：
2002
影响因子：
4.1
通讯作者：
Montealegre,F
中科院分区：
文献类型：
--
作者：
Pires,MC;Calux,MJF;Mori,JC;Montealegre,F
特应性皮炎（AD）患者常产生抗屋尘螨（如屋尘螨和屋尘螨）的IgG和IgE亚类抗体。花粉国内螨Blomia tropicalis在巴西流行，可导致AD的恶化。本研究的目的是评估皮肤对B的反应性。AD患者的热带提取物和非过敏受试者的对照组，并确定抗B的体外反应性。AD患者和对照组的非过敏性个体的血清中的IgG和IgE。受试者为36例确诊的AD患者，对照组为25例非过敏性个体。皮肤对B.通过点刺试验和抗B试验检测热带植物提取物。通过Western印迹检测血清中的热带IgG反应性。反B通过RAST测量血清中的热带IgE反应性。AD患者对B.比对照组的热带。在抗B抗体的存在之间观察到正相关。IgG、IgE和AD。AD患者对B.热带螨;因此，可将其视为暴露于该螨种属的患者发生AD加重的风险因素。
SummaryPatients with atopic dermatitis (AD) commonly develop antibodies of subclasses IgG and IgE to house dust mites, such asDermatophagoides pteronyssinusandD. farinae. The domestic miteBlomia tropicalisis prevalent in Brazil and can cause the exacerbation of AD. The objectives of this study were to assess skin reactivity toB. tropicalisextracts of AD patients and a control group of nonallergic subjects, and to determine thein vitroreactivity of anti‐B. tropicalisIgG and IgE in the serum of AD patients and a control group of nonallergic individuals. Subjects were 36 patients with confirmed AD and the controls were 25 nonallergic individuals. Skin sensitivity toB. tropicalisextracts was tested by the prick‐test, and anti‐B. tropicalisIgG reactivity in the serum was detected by the Western blot. Anti‐B. tropicalisIgE reactivity in the serum was measured by RAST. Patients with AD reacted 7.12 times more often to extracts fromB. tropicalis than the control group. A positive association was observed between the presence of anti‐B. tropicalisIgG and IgE and AD. AD patients showed a high degree of sensitization toB. tropicalis; it can thus be considered a risk factor for the development of AD exacerbations in patients exposed to this mite species.