Corneal Hysteresis With Intraocular Pressure of a Wide Range: A Test on Porcine Eyes
Corneal Hysteresis With Intraocular Pressure of a Wide Range: A Test on Porcine Eyes
复制标题
大范围眼压下的角膜迟滞：对猪眼的测试
DOI：
10.3928/1081597x-20131115-05
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发表时间：
2013-12-01
影响因子：
2.4
通讯作者：
Ren, Qiushi
中科院分区：
文献类型：
--
作者：
Tao, Chen;Han, Zhaolong;Ren, Qiushi
目得：目的：研究在低眼压和高眼压范围内角膜滞后（CH）与眼内压（IOP）的关系。通过在60 mm Hg的动态范围内改变滴液架的高度来改变IOP。在不同高度用眼反应分析仪（ORA; Reichert Ophthalmic Instruments，Depew，NY）测量CH和IOP。采用二阶多项式回归方法评估CH与IOP的非线性相关性。结果：CH表现出一个初始平台期，低IOP，然后随着IOP升高而降低，最高可达60 mm Hg。当IOP范围为11 - 25 mm Hg时，达到约6 - 8 mm Hg的最大CH值。Goldmann相关眼压（IOPg）与CH的非线性回归方程为CH =-0.0029xIOPg（2）+0.1005xIOPg + 5.2824，R-2 = 0.3676，P <0.05。结论：低眼压时CH相对恒定，高眼压时CH呈递减关系。这种非线性关系为理解CH在更宽范围的IOP值上的粘弹性性质提供了见解。猪眼的实验数据可能表明，在分析角膜对所施加的空气抽吸的变形响应时，应考虑IOP。
PURPOSE: To investigate the relationship between corneal hysteresis (CH) and intraocular pressure (IOP) using porcine eyes in the low to high IOP ranges.METHODS: In vitro porcine eyes were used to investigate the relationship of CH and IOP. IOP was altered by changing the height of a drip stand within the dynamic range of 60 mm Hg. CH and IOP were measured with the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Depew, NY) at different heights. Second-order polynomial regression method was employed to assess the nonlinear correlation of CH and IOP.RESULTS: CH demonstrated an initial plateau stage with low IOP, which then decreased as IOP increased to higher values up to 60 mm Hg. The maximum CH value of approximately 6 to 8 mm Hg was achieved when IOP ranged from 11 to 25 mm Hg. The nonlinear regression lines of Goldmann correlated IOP (IOPg) and CH can be described as CH = -0.0029 x IOPg(2) + 0.1005 x IOPg + 5.2824, R-2 = 0.3676, P < .05.CONCLUSIONS: CH was relatively constant for lower values of IOP and showed a decreasing relationship at higher values of IOP. This nonlinear relationship provides insight into understanding the viscoelastic nature of CH over a wider range of IOP values. The experimental data on porcine eyes may indicate that IOP should be taken into account when analyzing the deformation response of the cornea to an applied air puff.