Natural history of parainfluenza virus infection in childhood.
Natural history of parainfluenza virus infection in childhood.
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儿童时期副流感病毒感染的自然史。
DOI：
10.1016/s0022-3476(82)80113-3
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Ogra,PL
中科院分区：
文献类型：
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作者：
Welliver,R;Wong,DT;Choi,TS;Ogra,PL
为了确定生命早期副流感病毒感染的自然史，我们前瞻性地随访了130名婴儿和儿童从出生或几个月大时感染PV的证据。使用快速诊断技术，标准的组织培养感染性，血清学技术，我们能够记录在92%的这些婴儿的原发性PV感染，和重复感染的异型或同型PV株在49%的30个月大。增加患者年龄对降低PV感染导致的下呼吸道疾病的发生率没有显著影响。感染一种PV血清型在随后感染异型PV毒株时不提供针对LRTI的保护。与此相反，原发性PV感染提供了一个短暂的免疫期后，同型再感染LRTI。通过免疫荧光技术测定对PV的分泌性伊加反应。对引起初次感染和异型重复感染的PV毒株的抗体应答是短暂的，且幅度较小。同型再感染可显著提高抗PV分泌性抗体的产生。至少在生命早期，反复暴露于PV对于维持对PV感染引起的严重疾病的免疫力至关重要。
In order to determine the natural history of parainfluenza virus infection in early life, we followed prospectively 130 infants and children from birth or a few months of age for evidence of infection with PV. Using rapid diagnostic techniques, standard tissue culture infectivity, and serologic techniques we were able to document primary PV infection in 92% of these infants, and repeated infection with heterotypic or homotypic PV strains in 49% by 30 months of age. Increasing patient age had no significant effect in reducing the incidence of lower respiratory tract illness as a result of PV infection. Infection with one PV serotype provided no protection against LRTI at the time of subsequent infection with a heterotypic PV strain. In contrast, primary PV infection provided a brief period of immunity to LRTI upon homotypic reinfection. Secretory IgA responses to PV were determined by immunofluorescent techniques. Antibody response to PV strains causing primary infection and heterotypic repeated infection were transient and of low magnitude. Homotypic reinfection resulted in significantly enhaced production of secretory antibody to PV. At least in early life, repeated exposures to PV appear to be essential for maintaining immunity to severe forms of illness caused by PV infection.