Cellular function of p70S6K:: A role in regulating cell motility
Cellular function of p70S6K:: A role in regulating cell motility
复制标题
p70S6K的细胞功能：在调节细胞运动性方面的作用
DOI：
10.1046/j.1440-1711.2000.00928.x
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发表时间：
2000-08-01
影响因子：
4
通讯作者：
Crouch, MF
中科院分区：
文献类型：
--
作者：
Berven, LA;Crouch, MF
70 kDa核糖体S6激酶（p70（S6K））被许多促分裂原、生长因子和激素激活。p70（S6K）的活化通过在许多位点的磷酸化而发生，并且活化的激酶的主要靶标是40S核糖体蛋白S6，其是哺乳动物细胞中涉及蛋白质合成的机制的主要组分。除了参与调节翻译外，p70（S6K）激活还涉及细胞周期控制和神经元细胞分化。在该实验室获得的最新数据表明，p70（S6K）也可能在调节细胞运动性，细胞反应，这是重要的肿瘤转移，免疫反应和组织修复的功能。本文综述了p70（S6K）的调控及其细胞功能，并提出了p70（S6K）在调节细胞运动中的新功能。
The 70 kDa ribosomal S6 kinase (p70(S6K)) is activated by numerous mitogens, growth factors and hormones. Activation of p70(S6K) occurs through phosphorylation at a number of sites and the primary target of the activated kinase is the 40S ribosomal protein S6, a major component of the machinery involved in protein synthesis in mammalian cells. In addition to its involvement in regulating translation, p70(S6K) activation has been implicated in cell cycle control and neuronal cell differentiation. Recent data obtained in this laboratory suggests that p70(S6K) may also function in regulating cell motility, a cellular response that is important in tumour metastases, the immune response and tissue repair. The present paper reviews the regulation and cellular function of p70(S6K) and proposes a novel function of p70(S6K) in regulating cell motility.