Three-Component, One-Pot Sequential Synthesis of 1,3-Disubstituted 5-Arylhydantoins
Three-Component, One-Pot Sequential Synthesis of 1,3-Disubstituted 5-Arylhydantoins
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DOI：
10.1055/s-0028-1087352
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发表时间：
2008-12-01
期刊：
影响因子：
2
通讯作者：
Zanda, Matteo
中科院分区：
文献类型：
--
作者：
Olimpieri, Francesca;Volonterio, Alessandro;Zanda, Matteo
在非常温和的条件下和高产率地使N，N ′-取代的5-芳基乙内酰脲与α-Br（Cl）-芳基乙酸反应。当通过施陶丁格反应原位生成双酰亚胺时，该方法变成了一锅法、三组分顺序合成不同取代的5-芳基乙内酰脲库。
Reaction of carbodiimides with alpha-Br(Cl)-aryl acetic acids produces N,N'-substituted 5-arylhydantoins under very mild conditions and high yields. When the carbodiimides are generated in situ by Staudinger reaction, the process becomes a one-pot, three-component sequential synthesis of libraries of differently substituted 5-arylhydantoins.