Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population
Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population
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DOI：
10.1159/000114859
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Nishisaki, Tsuneo
中科院分区：
文献类型：
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作者：
Katahira, Masahito;Ishiguro, Toshiaki;Nishisaki, Tsuneo
目的：本研究旨在阐明日本人群中人类白细胞抗原的单倍型和与1型糖尿病易感性或抵抗力相关的基因类型。方法：比较日本人群中除暴发型1型糖尿病外的83例1型糖尿病患者和对照组的人类白细胞抗原DR-DQ单倍型和基因频率。根据发病年龄将患者分为4组(5~14岁、15~29岁、30~49岁、50~71岁)，比较每组间的单倍型频率。结果：DRB1*0405-DQB1*0401(DR4)、DRB1*0802-DQB1*0302(DR8)、DRB1*0901-DQB1*0303(DR9)和DRB1*1302-DQB1*0604(DR13)单倍型频率显著高于对照组。DRB1*1501-DQB1*0602和DRB1*1502-DQB1*0601单倍型频率显著低于对照组。患者组DR4/8、DR4/13、DR9/9和DR9/13等位基因频率显著高于对照组。DR13单倍型是30~49岁年龄组中最常见的单倍型，而除DR13以外的其他单倍型在其他年龄组中最常见。结论：DR4、DR8、DR9和DR13单倍型与日本患者1型糖尿病易感性有关。版权所有(C)2008 S.Karger AG，巴塞尔。
Aim: This study aims at clarifying the human leukocyte antigen haplotypes and genotypes conferring susceptibility or resistance to type 1 diabetes in the Japanese population. Methods: The frequencies of human leukocyte antigen DR-DQ haplotypes and genotypes were compared between 83 type 1 diabetic patients, except for fulminant type 1 diabetes, and control subjects in the Japanese population. The patients were divided by onset age into four groups (ages 5-14, 15-29, 30-49, and 50-71 years); the haplotype frequency was compared between each group. Results: The frequencies of DRB1*0405-DQB1*0401 (DR4), DRB1*0802-DQB1*0302 (DR8), DRB1*0901-DQB1*0303 (DR9), and DRB1*1302-DQB1* 0604 (DR13) haplotypes were significantly higher in the patients than in the control subjects. The frequencies of DRB1* 1501-DQB1*0602 and DRB1*1502-DQB1*0601 haplotypes were significantly lower in the patients than in the controls. The frequencies of DR4/8, DR4/13, DR9/9, and DR9/13 genotypes were significantly higher in the patients than in the control subjects. The DR13 haplotype was the most frequent haplotype in the age group 30-49 years, whereas the other haplotypes but DR13 were the most frequent in the other age groups. Conclusion: DR4, DR8, DR9, and DR13 haplotypes confer susceptibility to type 1 diabetes in Japanese patients. Copyright (C) 2008 S. Karger AG, Basel.