Leukocyte count as an independent predictor of recurrent ischemic events
Leukocyte count as an independent predictor of recurrent ischemic events
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DOI：
10.1161/01.str.0000124122.71702.64
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发表时间：
2004-05-01
期刊：
影响因子：
8.3
通讯作者：
Hacke, W
中科院分区：
文献类型：
--
作者：
Grau, AJ;Boddy, AW;Hacke, W
背景和目的-炎症标记物可预测首次缺血事件。我们研究了白细胞计数和分类计数是否可以预测高危人群中的复发事件和缺血事件，以及这些事件之前是否会出现急性加剧的炎症。方法 - 我们研究了 18558 名患有缺血性中风、心肌梗死或外周动脉疾病的患者，他们参加了氯吡格雷与阿司匹林治疗缺血性事件风险患者 (CAPRIE) 的试验，该研究比较了缺血性中风、心肌梗死或外周动脉疾病的发生率。阿司匹林或氯吡格雷随机治疗下发生梗塞或血管性死亡。随访期间经常评估白细胞计数。结果-与基线时白细胞计数最低的四分位数（8.2x10(9)/L）相比，缺血性脑卒中（相对风险1.30；P=0.007）、心肌梗死（相对风险1.56，P）的风险较高。
Background and Purpose-Inflammatory markers predict first-time ischemic events. We investigated whether leukocyte and differential counts predict recurrent events and ischemic events in high-risk populations, and whether such events are preceded by acutely exacerbated inflammation.Methods-We studied 18558 patients with ischemic stroke, myocardial infarction, or peripheral arterial disease who participated in the trial of Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE), a study that compared the occurrence of ischemic stroke, myocardial infarction, or vascular death under randomized treatment with aspirin or clopidogrel. Leukocyte counts were frequently assessed during followup.Results-Compared with the quartile with lowest leukocyte counts at baseline (8.2x10(9)/L) had higher risks for ischemic stroke (relative risk 1.30; P=0.007), myocardial infarction (relative risk 1.56, P