The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis.
The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis.
复制标题
丙酸杆菌属的存在。
DOI：
10.1111/j.1600-0420.2005.00638.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
V. Lee
中科院分区：
文献类型：
--
作者：
D. T. Liu;Chi;V. Lee
Yasuhara等人（2005）证明了丙酸杆菌属的存在。在结节病患者的玻璃体样本中。基于这一观察结果，作者进一步假设丙酸杆菌属的病原学作用。结节病葡萄膜炎的发病机制（Yasuhara et al. 2005）。作者引用了Ishige等人的开创性工作。等（1999）在15例结节病患者的淋巴结组织中鉴定痤疮丙酸杆菌DNA作为本研究的可能灵感。然而，他们似乎没有意识到，Ishige等人。（2005）最近指出痤疮丙酸杆菌可能是结节病的病原体，而不是真正的病原体。有趣的是，痤疮丙酸杆菌的这种最新旁观者作用可能会推翻痤疮丙酸杆菌和结节病之间最初的推测因果关系（Ishige et al. 2005）。鉴于这一新发现，我们渴望从Yasuhara及其同事那里了解他们对PCR结果的重新解释。
Yasuhara et al.(2005) demonstrated the presence of Propionibacterium spp. in vitreous samples from sarcoidosis patients. Based on this observation, the authors further postulated the aetiological role of Propionibacterium spp. in the pathogenesis of sarcoidosis uveitis (Yasuhara et al. 2005). The authors cited the pioneering work of Ishige et al.(1999) on the identification of Propionibacterium acnes DNA in lymph node tissue from 15 sarcoidosis patients as the possible inspiration for the present study. However, they appear to be unaware that Ishige et al.(2005) recently indicated the possibility of Propionibacterium acnes as a commensal rather than a true pathogeneic agent in sarcoidosis. Interestingly, this latest bystander role of Propionibacterium acnes might revoke the initial speculative causality between Propioni-bacterium acnes and sarcoidosis (Ishige et al. 2005). Given this new finding, we are keen to learn from Yasuhara and associates about their re-interpretation of their PCR result.