Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Nonlinearity in Tendon Tissue Mechanics.
Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Nonlinearity in Tendon Tissue Mechanics.
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DOI：
10.1007/s40883-016-0008-5
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发表时间：
2016-03-01
影响因子：
2.6
通讯作者：
Brown JL
中科院分区：
文献类型：
--
作者：
Banik BL;Lewis GS;Brown JL
再生医学在医学的未来中扮演着关键的角色。然而，在平衡干细胞、生物材料支架和生化因素以创造成功和有效的支架设计方面仍然存在挑战。本项目从力学性能和肌腱再生的初步间充质干细胞反应两方面分析支架结构。介绍了一种基于“中国指夹”设计的电纺纤维脚手架。这种独特的交叉纤维结构表现出与天然肌腱相似的非线性力学反应。力学性能测试表明，纤维取向的优化得到了具有“S”特征的曲线，呈现出脚趾区和线弹性区。该项目在血管工程、神经再生、韧带和肌腱组织工程等多个学科领域具有广阔的研究潜力。
Regenerative medicine plays a critical role in the future of medicine. However, challenges remain to balance stem cells, biomaterial scaffolds, and biochemical factors to create successful and effective scaffold designs. This project analyzes scaffold architecture with respect to mechanical capability and preliminary mesenchymal stem cell response for tendon regeneration. An electrospun fiber scaffold with tailorable properties based on a “Chinese-fingertrap” design is presented. The unique criss-crossed fiber structures demonstrate non-linear mechanical response similar to that observed in native tendon. Mechanical testing revealed that optimizing the fiber orientation resulted in the characteristic “S”-shaped curve, demonstrating a toe region and linear elastic region. This project has promising research potential across various disciplines: vascular engineering, nerve regeneration, and ligament and tendon tissue engineering.