Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
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DOI：
10.1016/j.bmcl.2005.11.102
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发表时间：
2006-03-15
影响因子：
2.7
通讯作者：
Dömling, A
中科院分区：
文献类型：
--
作者：
Antuch, W;Menon, S;Dömling, A
被认为能够破坏蛋白质-蛋白质相互作用的三联苯α-螺旋模拟物支架在结构上变形为易于处理和通用的多组分反应（MCR）骨架。设计，模块化平行库合成，初始细胞为基础的生物学数据，并初步在体外筛选的破坏Bcl-w/巴克蛋白质-蛋白质相互作用的MCR衍生支架的代表。(C)2006年由Elsevier Ltd.出版
A terphenyl alpha-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein-protein interaction by representatives of the MCR derived scaffold are presented. (C) 2006 Published by Elsevier Ltd.