TRANSFORMING GENES IN CHRONIC MYELOGENOUS LEUKEMIA
TRANSFORMING GENES IN CHRONIC MYELOGENOUS LEUKEMIA
复制标题
DOI：
10.1073/pnas.85.6.1952
复制
发表时间：
1988-03-01
影响因子：
11.1
通讯作者：
BISHOP, JM
中科院分区：
文献类型：
--
作者：
LIU, E;HJELLE, B;BISHOP, JM
慢性粒细胞白血病(CML)是一种以慢性期为特征的血液系统恶性肿瘤，它总是导致与急性白血病难以区分的“急变”。使用基于基因转移和肿瘤发生的敏感分析，我们寻找证据表明原癌基因的损伤可能在CML从慢性期到急变期的进展中起作用。在以这种方式检查的12名CML患者中，有7人携带转化基因。在6例慢性期患者和3例急变期患者的白血病细胞中检测到RAS原癌基因突变。此外，在1例慢性期和1例急变期患者中检测到一种未知的转化基因(既不是RAS也不是RAF)。我们的数据表明RAS基因突变在CML的发病机制中可能起着不同的作用。
Chronic myelogenous leukemia (CML) is a hematopoietic malignancy characterized by an indolent chronic phase that invariably leads to a "blast crisis" indistinguishable from acute leukemia. Using a sensitive assay based on gene transfer and tumorigenesis, we sought evidence that damage to protooncogenes might figure in the progression from the chronic to the blast phase of CML. Seven of the 12 patients with CML examined in this manner harbored transforming genes. Mutations in RAS protooncogenes were detected in the leukemic cells from 1 of 6 chronic-phase patients, and 3 of 6 blast-crisis patients. In addition, a presently unidentified transforming gene (neither RAS nor RAF) was detected in 1 patient with chronic phase and 1 with blast crisis. Our data indicate that mutations in RAS genes may play diverse roles in the pathogenesis of CML.