Ca2+ as an extracellular signal in bone
Ca2+ as an extracellular signal in bone
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DOI：
10.1016/j.ceca.2003.10.014
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发表时间：
2004-03-01
期刊：
影响因子：
4
通讯作者：
Riccardi, D
中科院分区：
文献类型：
--
作者：
Dvorak, MM;Riccardi, D
骨是钙的主要储存库，在维持细胞外游离离子化钙浓度（[Ca 2 +]（e））在其稳态范围（1.1-1.3 mM）内方面发挥重要作用。响应于急性高钙血症或低钙血症，Ca 2+被迅速转运到骨中或从骨中转运出来。骨转换（因此骨钙转换）通过成骨细胞和破骨细胞的代谢作用实现[Ca 2 +]（e）的长期校正，因为它们分别从骨中掺入或释放Ca 2+。这些过程由激素的作用调节，如甲状旁腺激素（PTH），其释放是[Ca 2 +]（e）的功能，并且是甲状旁腺中的e传感受体（CaR）。组织培养研究表明，骨细胞也受甲状旁腺中Ca-e（2+）敏感受体（CaR）的作用调节。组织培养研究表明，骨细胞也直接响应增加和减少[Ca 2 +]，在他们的附近，独立的全身因素。然而，需要进一步的研究来确定[Ca 2 +]（e）的急性和长期局部变化如何影响骨细胞及其参与的生理过程。此外，使骨细胞能够感知和响应[Ca 2 +]（e）的分子机制尚不清楚。与甲状旁腺细胞一样，骨细胞也表达CaR，越来越多的证据表明，这种受体参与了它们对细胞外离子环境变化的反应。(C)2003 Elsevier Ltd.保留所有权利。
Bone is the major sink and store for calcium and it fulfils essential roles in the maintenance of extracellular free ionised calcium concentration ([Ca2+](e)) within its homeostatic range (1.1-1.3 mM). In response to acute hypercalcaemia or hypocalcaemia, Ca2+ is rapidly transported into or out of bone. Bone turnover (and therefore bone Ca2+ turnover) achieves the long-term correction of the [Ca2+](e) by the metabolic actions of osteoblasts and osteoclasts, as they respectively incorporate or release Ca2+ from bone. These processes are regulated by the actions of hormones, such as parathyroid hormone (PTH), the release of which is a function of the [Ca2+](e), and is e sensing receptor (CaR) in the parathyroid gland. Tissue culture studies indicate that bone cells also regulated by the action of the Ca-e(2+)-sensing receptor (CaR) in the parathyroid gland. Tissue culture studies indicate that bone cells also directly respond to increasing and decreasing [Ca2+], in their vicinity, independently of the systemic factors. Nevertheless, further studies are necessary to identify how the acute and long-term local changes in [Ca2+](e) affect bone cells and the physiological processes they are involved in. Also, the molecular mechanisms which enable the bone cells to sense and respond to [Ca2+](e) are not clear. Like the parathyroid cells, bone cells also express the CaR, and accumulating evidence indicates the involvement of this receptor in their responses to the changing extracellular ionic environment. (C) 2003 Elsevier Ltd. All rights reserved.