Synthesis and Properties of pH-sensitive Sulfated Chitosan(SCS) Hydrogels
Synthesis and Properties of pH-sensitive Sulfated Chitosan(SCS) Hydrogels
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发表时间：
2008
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通讯作者：
Dong Sheng-xiong
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作者：
Dong Sheng-xiong
壳聚糖硫酸酯(SCS)是一种典型的两性聚电解质。本文采用均相合成法合成了高硫酸盐含量的SCS。将SCS与戊二醛(GA)进行交联制得两性水凝胶。用环境扫描电子显微镜(ESEM)对所得水凝胶的形态进行了表征。研究了制备条件和外界条件对SCS水凝胶溶胀度的影响。考察了SCS浓度、交联剂用量、SCS硫酸盐含量、外介质、pH值等因素对SCS水凝胶溶胀度的影响。结果表明，SCS水凝胶的溶胀度随SCS浓度的增加而增大；水凝胶在氯化钠溶液中的溶胀度远低于在水中的溶胀率。
Sulfated chitosan(SCS) is a typical kind of amphoteric polyelectrolyte.In this paper SCS with high sulfate content was synthesized by homogeneous synthesis.Crosslinking of SCS with glutaraldehyde(GA) results in the formation of polyampholyte hydrogels.The morphology of the resulting hydrogel was characterized using environmental scanning electron microscopy(ESEM).The effects of the preparation conditions and the external conditions on the swelling degree of the SCS hydrogels were investigated.The parameters investigated included SCS concentration,the dosage of cross-linker,sulfate content of SCS,external medium,and pH value.The swelling ratio(SR) of the SCS hydrogel increased with the increase of SCS concentration,and decreased with the increase of GA dosage or the sulfate content of SCS.The swelling ratio of the resulting hydrogel in sodium chloride solution was much lower than that in water.