Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response
Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response
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DOI：
10.1016/s0264-410x(02)00626-6
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发表时间：
2003-03-07
期刊：
影响因子：
5.5
通讯作者：
Bertino, JS
中科院分区：
文献类型：
--
作者：
Kim, MJ;Nafziger, AN;Bertino, JS
将60例健康无应答者随机分为肌注大剂量乙肝疫苗和肌注标准剂量乙肝疫苗加粒细胞-巨噬细胞集落刺激因子(GM-CSF)治疗0~2个月。分别于每次给药后1个月和末次给药后3个月检测乙肝表面抗原抗体。在无应答者中，两种方案在诱导血清保护方面是相同的。体重身高指数(WHI)
Sixty healthy nonresponders were randomized to receive intramuscular (IM) high dose hepatitis B virus (HBV) vaccine versus IM standard dose HBV vaccine plus granulocyte-macrophage colony-stimulating factor (GM-CSF) at 0-2 months. Antibody to hepatitis B surface antigen was measured 1 month after each dose and 3 months after the last dose. Two regimens were equivalent in eliciting seroprotection in nonresponders. Weight-height index (WHI)