Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer
Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer
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DOI：
10.3109/09513590.2013.879856
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发表时间：
2014-05-01
影响因子：
2
通讯作者：
Morimoto, Yoshiharu
中科院分区：
文献类型：
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作者：
Nishihara, Takuji;Hashimoto, Shu;Morimoto, Yoshiharu
本研究的目的是评估口服褪黑激素补充剂对辅助生殖技术项目患者卵母细胞和胚胎质量的疗效。所有患者均接受褪黑激素（3 mg/天）治疗至少2周。为了评估褪黑激素补充的累积效应，我们比较了完成两个治疗周期的患者的第一个周期（未补充褪黑激素）和第二个周期（褪黑激素补充）之间的周期结果。第一和第二周期之间的成熟率（p = 0.50）、囊胚率（p = 0.75）和优质囊胚率（p = 0.59）无显著差异。第2周期ICSI的受精率高于第1周期（69.3%比77.5%）。仅限于第一周期受精率低的患者（
The aim of this study was to evaluate the efficacy of oral melatonin supplementation on oocyte and embryo quality in patients in an assisted reproductive technologies program. All patients were treated for at least 2 weeks with melatonin (3 mg/day). To evaluate the cumulative effect of melatonin supplementation, we compared cycle outcomes between the first (no supplementation) and second cycles (melatonin supplementation) of patients who completed two treatment cycles. There were no significant differences in maturation rates (p = 0.50), blastocyst rates (p = 0.75), and the rate of good quality blastocysts (p = 0.59) between the first and second cycles. The fertilization rate of ICSI was higher in the second cycle than that in the first cycle (69.3 versus 77.5%). Being limited to patients with a low fertilization rate in the first cycle (