Peptide-modified vectors for nucleic acid delivery to neurons
Peptide-modified vectors for nucleic acid delivery to neurons
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DOI：
10.1016/j.jconrel.2008.06.012
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发表时间：
2008-12-18
影响因子：
10.8
通讯作者：
Pun, S. H.
中科院分区：
文献类型：
--
作者：
Kwon, E. J.;Bergen, J. M.;Pun, S. H.
神经元靶向核酸递送系统是实现神经系统疾病基因治疗潜力的重要技术。然而，神经元是难以使用非病毒载体转染的细胞，部分原因是这些细胞中存在特定且独特的递送挑战。我们研究了几种生物活性肽，了解它们协助克服哺乳动物细胞传递障碍的能力。我们在此总结了我们在开发和应用肽修饰聚阳离子进行核酸递送方面的最新进展。此外，我们提供的数据证明了使用多组分、肽修饰的聚阳离子将核酸递送至神经元的潜力。 (C) 2008 Elsevier B.V. 保留所有权利。
Neuron-targeted nucleic acid delivery systems are important technologies for realizing the potential of gene therapy for nervous system disorders. However, neurons are difficult cells to transfect using non-viral vectors due in part to the specific and unique delivery challenges present in these cells. We have investigated several bioactive peptides for their ability to assist in overcoming delivery barriers in mammalian cells. We summarize here our recent progress in developing and applying peptide-modified polycations for nucleic acid delivery. In addition, we present data demonstrating the potential of using multicomponent, peptide-modified polycations for nucleic acid delivery to neurons. (C) 2008 Elsevier B.V. All rights reserved.