The evolution of basal progenitors in the developing non-mammalian brain.
The evolution of basal progenitors in the developing non-mammalian brain.
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DOI：
10.1242/dev.127100
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Ono K
中科院分区：
文献类型：
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作者：
Nomura T;Ohtaka-Maruyama C;Yamashita W;Wakamatsu Y;Murakami Y;Calegari F;Suzuki K;Gotoh H;Ono K
不同的神经干/祖细胞亚型在胚胎发育过程中的扩增是必不可少的复杂的脑结构存在于各种脊椎动物物种。例如，在哺乳动物和鸟类中，增殖的神经元祖细胞短暂地出现在端脑脑室区的基底侧（基底祖细胞），在那里它们有助于新皮质及其同源结构的扩大。在胎盘哺乳动物中，这种增殖细胞群可以细分为几组，包括Tbr 2+中间祖细胞和基底放射状神经胶质细胞（bRG）。在这里，我们报告说，基础祖细胞在发展中的鸟类paleums显示出独特的形态和分子特征，类似的特征bRGs，祖细胞群体，是丰富的脑回哺乳动物新皮层。操纵LGN（Leu-Gly-Asn重复富集蛋白）和Cdk 4/细胞周期蛋白D1，神经祖细胞动力学的两个重要调节因子，揭示了基础祖细胞和Tbr 2+细胞是不同的细胞谱系在发展中的鸟类端脑。此外，我们发现了一个小种群的亚顶端有丝分裂细胞在发展中的各种各样的恐龙和两栖动物的大脑。我们的研究结果表明，独特的祖细胞亚型在哺乳动物和鸟类谱系中扩增，通过修改共同的机制，神经干/祖细胞的调节在哺乳动物的大脑进化。突出显示的文章：在发育中的小鸡paleurs，一个基础的祖细胞群体类似于哺乳动物皮质基底放射状神经胶质细胞，这表明这种细胞类型的一个更古老的进化起源。
The amplification of distinct neural stem/progenitor cell subtypes during embryogenesis is essential for the intricate brain structures present in various vertebrate species. For example, in both mammals and birds, proliferative neuronal progenitors transiently appear on the basal side of the ventricular zone of the telencephalon (basal progenitors), where they contribute to the enlargement of the neocortex and its homologous structures. In placental mammals, this proliferative cell population can be subdivided into several groups that include Tbr2+ intermediate progenitors and basal radial glial cells (bRGs). Here, we report that basal progenitors in the developing avian pallium show unique morphological and molecular characteristics that resemble the characteristics of bRGs, a progenitor population that is abundant in gyrencephalic mammalian neocortex. Manipulation of LGN (Leu-Gly-Asn repeat-enriched protein) and Cdk4/cyclin D1, both essential regulators of neural progenitor dynamics, revealed that basal progenitors and Tbr2+ cells are distinct cell lineages in the developing avian telencephalon. Furthermore, we identified a small population of subapical mitotic cells in the developing brains of a wide variety of amniotes and amphibians. Our results suggest that unique progenitor subtypes are amplified in mammalian and avian lineages by modifying common mechanisms of neural stem/progenitor regulation during amniote brain evolution. Highlighted article: In the developing chick pallium, a basal progenitor population resembles mammalian cortical basal radial glia, suggesting a more ancient evolutionary origin for this cell type.