Immunohistochemical localization of neprilysin in the human cerebral cortex:: inverse association with vulnerability to amyloid β-protein (Aβ) deposition
Immunohistochemical localization of neprilysin in the human cerebral cortex:: inverse association with vulnerability to amyloid β-protein (Aβ) deposition
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DOI：
10.1016/s0006-8993(01)02390-3
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发表时间：
2001-06-01
期刊：
影响因子：
2.9
通讯作者：
McGeer, PL
中科院分区：
文献类型：
--
作者：
Akiyama, H;Kondo, H;McGeer, PL
我们研究了脑啡肽酶（一种假定的β -淀粉样蛋白[Aβ]降解酶）在人死后脑组织中的免疫组织化学定位。在大脑皮层中，脑啡肽酶的免疫反应性较弱，但与海马和联合皮层相比，在初级躯体感觉皮层和初级视觉皮层中发现其分布相对密集。在阿尔茨海默病大脑中，脑啡肽酶阳性的营养不良性神经突出现在初级皮层的老年斑中，这一观察结果支持了脑啡肽酶阳性神经元突起相对丰富的观点。海马和联合皮层中脑啡肽酶的缺乏可能导致这些区域易受Aβ沉积的影响。（C）2001爱思唯尔科学出版社。版权所有。
We investigated the immunohistochemical localization of neprilysin, a putative amyloid beta -protein (A beta)-degrading enzyme, in postmortem human brain tissues. In the cerebral cortex, neprilysin immunoreactivity was weak, but relatively dense distribution was found in the primary somatosensory and visual cortices compared with the hippocampus and association cortices. In Alzheimer brain, neprilysin-positive dystrophic neurites occurred in senile plaques in the primary cortices, an observation that supports the relative abundance of neprilysin-positive neuronal processes. A paucity of neprilysin in the hippocampus and association cortices may contribute to the vulnerability of these areas to AP deposition. (C) 2001 Elsevier Science B.V. All rights reserved.