Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study.
Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study.
复制标题
MEND 研究中生命历程教育程度与乳腺癌等级的关联。
DOI：
10.5334/aogh.3142
复制
发表时间：
2021
影响因子：
2.9
通讯作者：
Akinyemiju T
中科院分区：
文献类型：
--
作者：
Gupta A;Jones K;Deveaux A;Bevel M;Salako O;Daramola A;Hall A;Alatise O;Ogun G;Adeniyi A;Ojo A;Ayandipo O;Olajide T;Olasehinde O;Arowolo O;Adisa A;Afuwape O;Olusanya A;Adegoke A;Tollefsbol TO;Arnett D;Newgard CB;Akinyemiju T
尼日利亚的乳腺癌 (BC) 年龄标准化死亡率是非洲国家中最高的，而且高级别癌症的发病率也高得不成比例。组织学分级是死亡率的有力预测因素，有证据表明受教育程度会影响癌症结果。我们描述了整个生命历程中的教育趋势与诊断时的 BC 等级之间的关联。对参加尼日利亚女性乳腺癌既定和新风险因素机制 (MEND) 研究的 224 名 BC 患者的数据进行了分析。参与者和父母（母亲和父亲）教育程度分为低（小学或以下）或高（中学或以上）。因此，每个参与者相对于每个父母的整个生命历程的教育趋势是确定的：稳定高、增加、减少或稳定低。 BC 等级分为高（3 级）或低（1-2 级）。大约 34% 的参与者、71% 的父亲和 85% 的母亲受教育程度较低。大约三分之一的参与者被诊断患有高级别 BC。 BC 等级低的参与者更有可能拥有受过高等教育的父亲 (p = 0.04)。在调整年龄、合并症、婚姻状况和乳房 X 光检查后，与父亲受教育程度较低的参与者相比，父亲受过高等教育的参与者患高级别 BC 的可能性要低 60%（aOR 0.41；95% CI 0.20 至 0.84）。与稳定的低生命历程教育相比，相对于父亲的稳定的高生命历程教育也与高等级 BC 的可能性显着降低相关（aOR 0.36；95% CI 0.15 至 0.87）。没有观察到参与者的教育、母亲的教育或相对于母亲的生命历程教育之间存在显着关联。早期生活的社会经济地位 (SES) 可能会影响 BC 等级。这值得进一步研究，为可能有助于减少尼日利亚高等级 BC 的政策提供信息。
Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. We characterize the association between educational trends across the life-course and BC grade at diagnosis. Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1–2). About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant’s education, mother’s education, or life-course education relative to mother. Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.
登录
查看更多内容
影响因子：
1.6
作者：
Liu Y;Zhang J;Huang R;Feng WL;Kong YN;Xu F;Zhao L;Song QK;Li J;Zhang BN;Fan JH;Qiao YL;Xie XM;Zheng S;He JJ;Wang K
通讯作者：
Wang K
影响因子：
10.3
作者：
Albano, Jessica D.;Ward, Elizabeth;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
2.9
作者：
Akinyemiju, Tomi;Ogunsina, Kemi;Braithwaite, Dejana
通讯作者：
Braithwaite, Dejana
DOI：
10.1177/0020731415585986
发表时间：
2015
期刊：
International journal of health services : planning, administration, evaluation
影响因子：
--
作者：
Hahn RA;Truman BI
通讯作者：
Truman BI
影响因子：
2.3
作者：
DeSantis, Carol;Jemal, Ahmedin;Ward, Elizabeth
通讯作者：
Ward, Elizabeth