Intrinsic bursting enhances the robustness of a neural network model of sequence generation by avian brain area HVC
Intrinsic bursting enhances the robustness of a neural network model of sequence generation by avian brain area HVC
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DOI：
10.1007/s10827-007-0032-z
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发表时间：
2007-12-01
影响因子：
1.2
通讯作者：
Seung, H. Sebastian
中科院分区：
文献类型：
--
作者：
Jin, Dezhe Z.;Ramazanoglu, Fethi M.;Seung, H. Sebastian
已知鸟类大脑HVC区域对于鸟鸣的产生是重要的。在斑胸草雀中，HVC中的每个RA投射神经元在歌曲主题期间发出单个尖峰脉冲。神经元群体以精确定时的、刻板的顺序被激活。我们提出了一个模型，这些突发序列依赖于两个假设。首先，我们假设突发的顺序反映在神经元之间的兴奋性突触连接中。其次，我们提出神经元本质上是爆发的，因此爆发持续时间由细胞特性决定。我们的模型产生的突发序列类似于在HVC中观察到的。如果从模型中去除固有的突发，也可以产生突发序列。然而，它们需要对突触强度进行更多的微调，因此不太稳健。在我们的模型中，内在爆发是由树突状细胞的钙峰引起的，而索马中强的峰频率适应有助于爆发终止。
Avian brain area HVC is known to be important for the production of birdsong. In zebra finches, each RA-projecting neuron in HVC emits a single burst of spikes during a song motif. The population of neurons is activated in a precisely timed, stereotyped sequence. We propose a model of these burst sequences that relies on two hypotheses. First, we hypothesize that the sequential order of bursting is reflected in the excitatory synaptic connections between neurons. Second, we propose that the neurons are intrinsically bursting, so that burst duration is set by cellular properties. Our model generates burst sequences similar to those observed in HVC. If intrinsic bursting is removed from the model, burst sequences can also be produced. However, they require more fine-tuning of synaptic strengths, and are therefore less robust. In our model, intrinsic bursting is caused by dendritic calcium spikes, and strong spike frequency adaptation in the soma contributes to burst termination.