Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice.
Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice.
复制标题
磁共振显微镜定量马凡综合征小鼠的疾病进展。
DOI：
10.1002/jmri.10279
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Fayad,ZahiA
中科院分区：
文献类型：
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作者：
Itskovich,VitaliiV;Lieb,Mark;Aguinaldo,JuanGilbertoS;Samber,DanielD;Ramirez,Francesco;Fayad,ZahiA
目的应用无创磁共振显微镜（MRM）观察马凡氏综合征（MFS）小鼠模型的动脉瘤病变。材料与方法共8只野生型（WT）和MFS小鼠采用MRM成像；其中4只动物在8周内的三个不同时间点进行成像，其余动物在一个时间点进行成像。主动脉的最大横截面积是通过人工描摹和自动方法从心脏和呼吸门控明亮的血液图像中测量出来的。建立了野生型和突变型小鼠主动脉尺寸与年龄的关系，以及野生型和突变型小鼠主动脉尺寸的差异。结果在所有时间点，WT和突变小鼠的最大主动脉横断面积差异显著（P< 0.05）， MFS小鼠的主动脉面积更大。MFS小鼠主动脉尺寸与年龄呈正相关（r = 0.80），且在第14 ~ 22周显著增加（P< 0.05）。mrm检测到WT和突变小鼠随着时间的推移主动脉大小的差异，证明了一种无创技术评估MFS小鼠潜在治疗方法的潜力。j .增效。的原因。成像2003;17:435 - 439。©2003 Wiley‐Liss, Inc。
PurposeTo use noninvasive magnetic resonance microscopy (MRM) to examine aneurysmal disease in the mouse model of Marfan syndrome (MFS).Materials and MethodsA total of eight wild‐type (WT) and MFS mice were imaged using MRM; four of them at three different time points over an 8‐week period and the remaining animals were imaged at one time point. The maximal cross‐sectional area of the aorta was measured by manual tracing and by automated means from combined cardiac and respiratory‐gated bright‐blood images. Relationships between aortic size and age and the differences between WT and mutant mice aortic size were established.ResultsMaximal cross‐sectional aortic areas differed significantly (P< 0.05) between WT and mutant mice for all time points, with MFS mice having larger aortic size. There was a positive correlation between aortic size and age in MFS mice (r = 0.80) with a significant increase from the 14th to the 22nd week (P< 0.05).ConclusionMRM detected the differences in aortic size between WT and mutant mice over time, demonstrating a potential for noninvasive technique for the assessment of potential therapies in MFS mice. J. Magn. Reson. Imaging 2003;17:435–439. © 2003 Wiley‐Liss, Inc.