The spliceosome as an indicted conspirator in myeloid malignancies.

The spliceosome as an indicted conspirator in myeloid malignancies.
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DOI:
10.1016/j.ccr.2011.10.004
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发表时间:
2011-10-18
期刊:
影响因子:
50.3
通讯作者:
Levine R
Levine R
中科院分区:
医学1区
文献类型:
--
作者:
Abdel-Wahab O;Levine R

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Data from two recent studies of whole-exome sequencing of myelodysplastic syndrome (MDS) suggests spliceosome mutations have clinical relevance. Identifying the impact of these mutations on pre-mRNA splicing and MDS pathogenesis holds promise for targeted modulation of mRNA splicing in MDS.
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