Serum carotenoid, tocopherol and retinol concentrations and breast cancer risk in the E3N-EPIC study
Serum carotenoid, tocopherol and retinol concentrations and breast cancer risk in the E3N-EPIC study
复制标题
DOI：
10.1002/ijc.25138
复制
发表时间：
2010-09-01
影响因子：
6.4
通讯作者：
Chajes, Veronique
中科院分区：
文献类型：
--
作者：
Maillard, Virginie;Kuriki, Kiyonori;Chajes, Veronique
水果和蔬菜摄入量对乳腺癌风险的保护作用的证据不一致。基于血液类胡萝卜素摄入量作为个体水果和蔬菜消费量生物标志物的流行病学队列研究仍然很少，结果也不一致。研究人群包括E3 N研究中的女性，E3 N研究是欧洲癌症和营养前瞻性调查（EPIC）的大型法国部分。在平均7年的随访中，在19,934名完成饮食调查问卷并在基线（1995-1998年）有可用血液样本的妇女中，有366例侵袭性乳腺癌（84名绝经前妇女和282名绝经后妇女）被纳入研究。对照组在年龄、采血时的绝经状态、采血时的空腹状态、日期和采血中心方面随机匹配。血清类胡萝卜素，生育酚和视黄醇的浓度进行了评估，高压液相色谱法。通过血清微量营养素浓度的五分位数计算乳腺癌风险的比值比，该比值比经确定的乳腺癌风险因素调整后。乳腺癌风险与血清类胡萝卜素之间无显著相关性（最高与最低五分位数，比值比（OR）= 0.74，95%置信区间（CI）= 0.47-1.16，趋势p = 0.38），生育酚（OR = 0.68，95%CI = 0.41-1.10，趋势p为0.26）和视黄醇（OR = 0.85，95%CI = 0.53-1.35，趋势p = 0.34）我们的研究结果并不支持水果和蔬菜中的亲脂性抗氧化微量营养素可以预防乳腺癌的假设。癌症，至少在绝经后妇女中。
Evidence of a protective effect of fruit and vegetable intake on breast cancer risk is inconsistent. Epidemiologic cohort studies based on blood carotenoid intakes as biomarkers of consumption of fruits and vegetable in individuals are still scare and findings are discrepant. The study population included women in the E3N Study, the large French component of the European Prospective Investigation into Cancer and Nutrition (EPIC). During an average of 7 years follow-up, 366 cases of incident invasive breast cancer (84 premenopausal women and 282 postmenopausal women) among 19,934 women who completed a dietary questionnaire and had available blood samples at baseline (1995-1998) were included in the study. Controls were randomly matched on age, menopausal status at blood collection, fasting status at blood collection, date and collection center. Serum carotenoids, tocopherols and retinol concentrations were assessed by high pressure liquid chromatography. Odds ratios for breast cancer risk adjusted for established breast cancer risk factors were calculated by quintile of serum micronutrient concentrations. No significant associations between breast cancer risk and serum carotenoids (highest versus lowest quintile, odds ratio (OR) = 0.74, 95% confidence interval (CI) = 0.47-1.16, p for trend 0.38), tocopherols (OR = 0.68, 95% CI = 0.41-1.10, p for trend 0.26) and retinol (OR = 0.85, 95% CI = 0.53-1.35, p for trend 0.34) were found. Our findings did not support the hypothesis that lipophilic antioxidant micronutrients found in fruits and vegetables protect against breast cancer, at least in postmenopausal women.