Comparison between kidney and hemoperfusion for paraquat elimination.
Comparison between kidney and hemoperfusion for paraquat elimination.
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DOI：
10.3346/jkms.2009.24.s1.s156
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发表时间：
2009-01
影响因子：
4.5
通讯作者：
Hong, Sae-Yong
中科院分区：
文献类型：
--
作者：
Kang, Moon-Soo;Gil, Hyo-Wook;Yang, Jong-Oh;Lee, Eun-Young;Hong, Sae-Yong
急性百草枯中毒的死亡率取决于血液中百草枯的浓度。已有研究表明，肾脏能有效地清除PQ。然而，急性PQ中毒常可观察到早期肾功能恶化。这项研究旨在比较血液灌流(HP)和肾脏消除PQ的效果，同时考虑到肾脏的功能恶化。测定急性PQ中毒患者在HP治疗过程中肾脏排泄量和HP排泄量。HP药盒的PQ清除量和实际清除量分别为111±11m L/m in(范围：13.2-162.2 m L/m in)和251.4±506.3 mg(范围：4.6-1,655.7 m g)。肾清除量和实际排泄量分别为79.8±56.0mL/min(9.7~177.0)和75.4±73.6 mg(4.9~245.8)。随着内生肌酐清除量的降低，HP对PQ的清除与肾清除一样有效，甚至更有效。综上所述，急性PQ中毒患者抢救生命必须提供早期Hp治疗。
The mortality rate of acute paraquat (PQ) poisoning depends on the PQ concentration in the blood. It has been shown that the kidneys eliminate PQ effectively. However, early renal function deterioration is frequently observed in acute PQ intoxication. This study is designed to compare the efficacy of PQ elimination with hemoperfusion (HP) and kidneys, taking into account the functional deterioration of the kidneys. The amount of renal and HP excretion of PQ were measured during the procedure of HP in patients with acute PQ intoxication. The PQ clearance and the actual amount of PQ elimination by the HP cartridge during the HP procedure were 111±11 mL/min (range; 13.2-162.2 mL/min) and 251.4±506.3 mg (range; 4.6-1,655.7) each. While, the renal clearance and actual amount of renal elimination of PQ was 79.8±56.0 mL/min (range; 9.7-177.0) and 75.4±73.6 mg (range; 4.9-245.8). As the creatinine clearance decreased, the PQ elimination by HP was as effective as or more effective than the renal elimination. In conclusion, early HP must be provided for life saving treatment in patients with acute PQ intoxication.