Relationship of Total Hemoglobin in Subcutaneous Adipose Tissue with Whole-Body and Visceral Adiposity in Humans
Relationship of Total Hemoglobin in Subcutaneous Adipose Tissue with Whole-Body and Visceral Adiposity in Humans
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DOI：
10.3390/app9122442
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发表时间：
2019-06-02
影响因子：
2.7
通讯作者：
Hamaoka, Takafumi
中科院分区：
文献类型：
--
作者：
Kuroiwa, Miyuki;Fuse, Sayuri;Hamaoka, Takafumi
全身和内脏脂肪过多是导致代谢性疾病的危险因素。我们假设腹部皮下脂肪组织（SAT（ab））中的总血红蛋白浓度（total-Hb）（白色脂肪组织（WAT）血管分布的指标）与发生代谢性疾病（如全身和内脏肥胖）的风险因素呈负相关。我们测试了140名参与者（45名男性和95名女性）的腹部组织的光学特性，这些参与者显然是健康的个体，中位年龄为39岁。他们的体脂百分比中位数为25.4%，内脏脂肪面积为50.4 cm（2），SAT（ab）厚度为1.05 cm。这些测试是使用近红外时间分辨光谱（NIRTRS）进行的，光管间距为2 cm。为了区分SAT（ab）的片段（Seg（SAT））和肌肉和SAT（ab）的混合物（Seg（SAT+Mus）），使用最小二乘均值方法使用（总Hb）相对于SAT（ab）厚度的斜率来分析阈值。根据逻辑回归分析的结果，在Seg（SAT）数据中，体脂百分比和内脏脂肪面积仍然是（总Hb）的显著预测因子（分别为p = 0.005和p = 0.043）（SAT（ab）厚度无影响）。我们的结论是，简单，快速，非侵入性NIRTRS测定（总血红蛋白）在WAT可能是一个有用的参数，用于评估代谢性疾病的危险因素。
High whole-body and visceral adiposity are risk factors that can cause metabolic diseases. We hypothesized that the total hemoglobin concentration (total-Hb) in abdominal subcutaneous adipose tissue (SAT(ab)), an indicator of white adipose tissue (WAT) vascularity, correlates negatively with risk factors for developing metabolic diseases, such as whole-body and visceral adiposity. We tested the optical characteristics of abdominal tissue in 140 participants (45 men and 95 women) who were apparently healthy individuals with a median age of 39 years. They also had a median body fat percentage of 25.4%, a visceral fat area of 50.4 cm(2), and a SAT(ab) thickness of 1.05 cm. These tests were conducted using near-infrared time-resolved spectroscopy (NIRTRS) with a 2-cm optode separation. To distinguish the segments of SAT(ab) (Seg(SAT)) and the mixture of muscle and SAT(ab) (Seg(SAT+Mus)), the threshold was analyzed using the slopes of (total-Hb) against the thickness of SAT(ab) using the least-squares mean method. According to the results from the logistic regression analysis, the percentage of body fat and visceral fat area remained significant predictors of the (total-Hb) (p = 0.005 and p = 0.043, respectively) in the data for Seg(SAT) (no influence from the SAT(ab) thickness). We conclude that simple, rapid, and noninvasive NIRTRS-determined (total-Hb) in WAT could be a useful parameter for evaluating risk factors for metabolic diseases.