A Study of Serum Antibody Activity in Workers with Occupational Exposure to Diphenylmethane Diisocyanate
A Study of Serum Antibody Activity in Workers with Occupational Exposure to Diphenylmethane Diisocyanate
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二苯甲烷二异氰酸酯职业接触工人血清抗体活性研究
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
M. Chan
中科院分区：
文献类型：
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作者：
K. Tse;A. Johnson;H. Chan;M. Chan
对76名职业暴露于二苯基甲烷二异氰酸酯（MDI）的铸造工人进行了致敏性研究。10名工人有哮喘的临床证据，40名有非哮喘呼吸道症状，26名无症状。2名工人检测到MDI特异性IgE抗体（2.6%），5名工人检测到特异性IgG抗体（6.6%）。10例哮喘患者的IgE和IgG抗体的患病率高于非哮喘组。抗对嘌呤单异氰酸酯抗体的流行率与抗MDI抗体没有显著差异，在RAST抑制试验中，两种半抗原决定因子都表现出高度的交叉反应性。鉴于这些血清抗体在这组工人中相当低的患病率，体液免疫机制在MDI诱导的哮喘中的作用尚不清楚。
The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non‐asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to MDI were found in two workers (2.6%) and specific IgG antibodies, in five workers (6.6%). The prevalence of IgE and IgG antibodies was higher in the 10 subjects with asthma than in the non‐asthmatic group. The prevalence of anti‐paratolyl‐monoisocyanate antibodies was not significantly different from that of anti‐MDI antibodies, and both haptenic determinants displayed a high degree of cross‐reactivity in the RAST inhibition test. The role of humoral immunological mechanisms in MDI‐induced asthma is unclear in view of the rather low prevalence of these serum antibodies in this group of workers.