Postnatal growth and the heterogeneity of preschool wheeze.
Postnatal growth and the heterogeneity of preschool wheeze.
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产后生长和学龄前喘息的异质性。
DOI：
10.1016/j.jpeds.2014.10.069
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Martinez,FernandoD
中科院分区：
文献类型：
--
作者：
Voraphani,Nipasiri;Martinez,FernandoD
近几十年来，肥胖和哮喘的患病率一直在增加，引发人们猜测它们可能存在因果关系。多项流行病学研究已证实超重状况与学龄儿童哮喘的发病率和患病率之间存在关联。 1-3 由于生长轨迹似乎是在生命早期就已确定，4 人们对探索这种早期轨迹与随后出现的哮喘样症状之间的关系产生了相当大的兴趣。有人提出，生命早期关键时期的产前和产后环境损害有可能影响呼吸系统的后续发育，更具体地说，影响哮喘的易感性和肺功能不良。 5, 6在本期杂志中，de Korte-de Boer 等人将参与 LucKi 人口出生队列的 566 名儿童的产后生长速度与 3 岁以内的喘息联系起来。 7 确定每个随访年龄的体重、身高和 BMI 的标准差评分 (SDS)，并利用两个时间点 SDS 评分之间的差异，计算 3 个时间段内每个生长特征的相对生长率：1-7 个月、7-14 个月和 2-3 岁。家长报告了相应年龄（即 7 个月、14 个月和 3 岁）喘息的发生情况。体重和体重指数增加率与儿童早期并发喘息无关。
The prevalence of both obesity and asthma has been increasing in recent decades, giving rise to speculation that they may be causally related. An association of overweight status with the incidence and prevalence of asthma in school age children has been confirmed in several epidemiologic studies. 1–3 Because growth trajectories appear to be established very early in life, 4 there has been a considerable interest in exploring the relationship between such early trajectories and the subsequent development of asthma-like symptoms. It has been proposed that prenatal and postnatal environmental insults during critical periods in early life have the potential to affect subsequent development of the respiratory system, and more specifically, susceptibility to asthma and poor lung function. 5, 6In this issue of The Journal, de Korte-de Boer et al relate postnatal growth rate to wheezing up to 3 years of age among 566 children participating in the LucKi population-based birth cohort. 7 Standard deviation scores (SDS) for weight, height, and BMI at each follow-up age were determined, and relative growth rate for each growth characteristic was calculated over 3 time periods: between 1–7 months, between 7–14 months, and between 2–3 years of age, using the difference between the SDS score at two time points. Occurrence of wheezing was parentally reported at the corresponding ages, namely, 7 months, 14 months, and 3 years. Rates of weight and BMI gain were not associated with concurrent wheezing during early childhood.