Mathematical model for G-CSF administration after chemotherapy
Mathematical model for G-CSF administration after chemotherapy
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DOI：
10.1016/j.jtbi.2008.09.043
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发表时间：
2009-03-07
影响因子：
2
通讯作者：
Mackey, Michael C.
中科院分区：
文献类型：
--
作者：
Foley, Catherine;Mackey, Michael C.
粒细胞集落刺激因子（G-CSF）在临床上用于治疗化疗诱导的中性粒细胞减少症（低中性粒细胞水平）。在这里，我们提出了一个延迟微分方程模型的调节中性粒细胞的生产占G-CSF的影响。使用相结合的分析和数值模拟，我们使用这个模型来研究化疗后延迟G-CSF治疗的两种重组形式的G-CSF（非格司亭和培非格司亭）的影响。我们还研究了不同的非格司亭治疗持续时间的后果。我们发现，不同的起始日或持续时间的G-CSF治疗可以导致不同的中性粒细胞计数的定性反应。这些变化可以用数学模型中两个稳定解的共存来解释。(C)2008爱思唯尔有限公司保留所有权利。
Granulocyte-colony stimulating factor (G-CSF) is used clinically for treating chemotherapy-induced neutropenia (low neutrophil levels). Here we present a delay differential equation model for the regulation of neutrophil production that accounts for the effects of G-CSF. Using a combination of analysis and numerical simulations, we use this model to study the effects of delaying G-CSF treatment following chemotherapy for two recombinant forms of G-CSF (filgrastim and pegfilgrastim). We also examine the consequences of varying the duration of filgrastim treatment. We found that varying the starting day or the duration of G-CSF treatment can lead to different qualitative responses in the neutrophil count. These changes can be explained by the coexistence of two stable solutions in the mathematical model. (C) 2008 Elsevier Ltd. All rights reserved.