Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats
Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats
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DOI：
10.1093/jn/131.1.46
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发表时间：
2001-01-01
影响因子：
4.2
通讯作者：
Cousins, RJ
中科院分区：
文献类型：
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作者：
Liuzzi, JP;Blanchard, RK;Cousins, RJ
锌代谢在多种饮食摄入量中得到良好调节，有助于维持细胞锌依赖性功能。转运蛋白分子的表达影响锌在血浆和细胞内膜的流入和流出，有助于这种调节。我们在大鼠中检查了锌转运蛋白 1、2 和 4（ZnT-1、ZnT-2 和 ZnT-4）对膳食锌的比较反应。 ZnT-1 和 ZnT-4 广泛表达，而 ZnT-2 仅限于小肠、肾脏、胎盘，在某些情况下还表达于肝脏。当锌摄入量较低时（ZnT-1 > ZnT-4）。这些数据提供的证据表明，在动物模型中，锌转运蛋白的表达在生理相关条件下对锌有反应。
Zinc metabolism is well regulated over a wide range of dietary intakes to help maintain cellular zinc-dependent functions. Expression of transporter molecules, which influence zinc influx and efflux across the plasma and intracellular membranes, contributes to this regulation. We have examined in rats the comparative response of zinc transporters 1, 2, and 4 (ZnT-1, ZnT-2 and ZnT-4) to dietary zinc. ZnT-1 and ZnT-4 are expressed ubiquitously, whereas ZnT-2 is limited to small intestine, kidney, placenta and, in some cases, the liver. When zinc intake was low ( ZnT-1 > ZnT-4. These data provide evidence that, in an animal model, zinc transporter expression is responsive to zinc under physiologically relevant conditions.