Fullerene-based antioxidants and neurodegenerative disorders
Fullerene-based antioxidants and neurodegenerative disorders
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DOI：
10.1016/s1353-8020(00)00064-x
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发表时间：
2001-07-01
影响因子：
4.1
通讯作者：
O'Malley, KL
中科院分区：
文献类型：
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作者：
Dugan, LL;Lovett, EG;O'Malley, KL
巴克敏斯特富勒烯（C-60）衍生物的水溶性衍生物是一类独特的化合物，具有有效的抗氧化性能。对其中一类化合物丙二酸C-60衍生物（羧基富勒烯）的研究表明，它们能够消除超氧阴离子和H2 O2，并且是脂质过氧化的有效抑制剂，同时，羧基富勒烯在皮层细胞培养中表现出对兴奋性毒性、凋亡和代谢损伤的强大神经保护作用。它们还能够从MPP+和6-羟基多巴胺诱导的变性中拯救中脑多巴胺能神经元。虽然这些化合物的体内数据有限，但我们以前曾报道过，在家族性肌萎缩性侧索硬化症（FALS）小鼠模型中，全身给予C-3羧基富勒烯异构体可延迟运动恶化和死亡。在其他CNS疾病状态的动物模型中正在进行的研究表明，这些新型抗氧化剂是潜在的神经保护剂：用于其他神经退行性疾病，包括帕金森病的药物。(C)2001爱思唯尔科技有限公司版权所有。
Water-soluble derivatives of buckminsterfullerene (C-60) derivatives are a unique class of compounds with potent antioxidant properties. Studies on one class of these compounds, the malonic acid C-60 derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H2O2, and were effective inhibitors of lipid peroxidation, as well, Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP+ and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C-3 carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants art: potential neuroprotective: agents for other neurodegenerative disorders, including Parkinson's disease. (C) 2001 Elsevier Science Ltd. All rights reserved.