PROLIFERATIVE ACTIVITY OF BENIGN HUMAN-PROSTATE, PROSTATIC ADENOCARCINOMA AND SEMINAL-VESICLE EVALUATED BY THYMIDINE LABELING
PROLIFERATIVE ACTIVITY OF BENIGN HUMAN-PROSTATE, PROSTATIC ADENOCARCINOMA AND SEMINAL-VESICLE EVALUATED BY THYMIDINE LABELING
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DOI：
10.1016/s0022-5347(17)53506-5
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发表时间：
1982-01-01
影响因子：
6.6
通讯作者：
MARTIN, SA
中科院分区：
文献类型：
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作者：
MEYER, JS;SUFRIN, G;MARTIN, SA
体外测定良性前列腺、精囊上皮、间质及前列腺腺癌上皮胸腺嘧啶标记指数（TLI）。正常外周（后）前列腺区上皮细胞TLI平均值为0.12%，正常中央（深）前列腺区上皮细胞TLI平均值为0.11%。正常间质TLI平均值分别为0.08%和0.06%。结节性增生的上皮平均TLI为0.31%，与正常上皮差异有统计学意义（P < 0.05），间质平均TLI升高（0.16%,P < 0.1）。前列腺腺癌的平均TLI为0.90%（范围0.14 ~ 3.90%），显著高于正常上皮（P < 0.001）和结节性增生上皮（P < 0.05）。TLI随组织学分级、核仁大小和数量的增加而增加的趋势不显著。这些数据支持上皮和间质增生参与结节增生，并表明正常前列腺的基础增生率较低。前列腺腺癌相对于其他恶性肿瘤的低TLI与其通常缓慢的进展过程相一致。精囊上皮的低增殖率（平均TLI为0.02%）可能是精囊癌罕见的原因。
The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normla peripheral (posterior) prostatic zone was 0.12%, and that of the normal central (deep) zone was 0.11%. Mean normal stromal TLI were 0.08 and 0.06%, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31%, which differs significantly from normal epithelium (P < 0.05), and the mean stromal TLI was also increased (0.16%, P < 0.1). The mean TLI of prostatic adenocarcinomas was 0.90% (range 0.14-3.90%) which was significantly higher than for either normal epithelium (P < 0.001) or epithelium of nodular hyperplasia (P < 0.05). Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium (mean TLI 0.02%) may account for the rarity of seminal vesicular carcinomas.