Associative conditioning of single sensory neurons suggests a cellular mechanism for learning.
Associative conditioning of single sensory neurons suggests a cellular mechanism for learning.
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单个感觉神经元的联想调节暗示了学习的细胞机制。
DOI：
10.1126/science.6294834
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Byrne,JH
中科院分区：
文献类型：
--
作者：
Walters,ET;Byrne,JH
联想学习的细胞模拟已被证明在单个感觉神经元的尾退缩反射。在对动物尾部进行致敏性电击之前，通过细胞内电流注射激活的感觉细胞，其与尾部运动神经元的单突触连接明显比不与尾部电击配对的细胞内刺激或单独接受尾部电击训练的细胞更容易被激活。这种联想效应是迅速获得的，并表现为异突触促进的时间特异性放大。结果表明，活动依赖性神经调节可能是联想信息存储的一种机制，并指出可能参与神经关联形成的亚细胞过程的各个方面。
A cellular analog of associative learning has been demonstrated in individual sensory neurons of the tail withdrawal reflex ofAplysia. Sensory cells activated by intracellular current injection shortly before a sensitizing shock to the animal's tail display significantly more facilitation of their monosynaptic connections to a tail motor neuron than cells trained either with intracellular stimulation unpaired to tail shock or with tail shock alone. This associative effect is acquired rapidly and is expressed as a temporally specific amplification of heterosynaptic facilitation. The results suggest that activity-dependent neuromodulation may be a mechanism underlying associative information storage and point to aspects of subcellular processes that might be involved in the formation of neural associations.