Stimulation of follicular melanogenesis in the mouse by topical and injected melanotropins.
Stimulation of follicular melanogenesis in the mouse by topical and injected melanotropins.
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通过局部和注射促黑素激素刺激小鼠滤泡黑素生成。
DOI：
10.1111/1523-1747.ep12471337
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Hadley,ME
中科院分区：
文献类型：
--
作者：
Levine,N;Lemus-Wilson,A;Wood,SH;AbdelMalek,ZA;Al-Obeidi,F;Hruby,VJ;Hadley,ME
本文研究了促黑素细胞激素（α-MSH）及其类似物对小鼠（C57 BL/6 JA γ）卵泡黑素生成的影响。(Nle4[Nle 4，D-Phe 7]-α-MSH及其类似物Ac-[Nle 4，D-Phe 7]-α-MSH 4 -11-NH 2和Ac-[Nle 4，D-Phe 7]-α-MSH 4 -10-NH 2，在皮下注射浓度比天然激素α-MSH低100倍时，可刺激褐黑素向真黑素转化。此外，促黑素激素类似物在局部应用于小鼠皮肤时刺激毛囊真黑素生成。促黑素素经皮递送至全身循环，如在远离局部施用部位的区域中的天赋卵泡中刺激枯黑素生成的事实所证明的。这些结果表明，肽激素类似物可以跨皮肤运输。促黑素类似物的独特作用可能与这些肽是不可生物降解的，因此对黑素细胞发挥长期作用的事实有关。这些化合物可能证明对正常皮肤黑素生成的研究和对人类的脂肪过少症的治疗是重要的。
The effects of melanocyte-stimulating hormone (α-MSH) and related analogs on follicular melanogenesis in the mouse (C57BL/6JAγ) were studied. (Nle4,D-Phe7]-α-MSH and the related fragment analogues Ac-[Nle4,D-Phe7]-α- MSH4–11-NH2and Ac-[Nle4,D-Phe7]-α-MSH4–10-NH2, stimulated the conversion of pheomelanogenesis to eumelanogenesis when subcutaneously injected at concentrations 100-fold lower than tile native hormone, α-MSH. In addition, the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice. The melanotropins were transdermally delivered to the systernic circulation as evidenced by the fact that cumelano- genesis was stimulated in flair follicles in areas distant from the site of topical application. These results demonstrate that peptide hormone analogs can be transported across the skin. The unique actions of the melanotropin analogs may relate to the fact that these peptides are nonbiodegradable and thus exert prolonged actions on melanocytes. These compounds may prove important for studies on normal integumental melanogenesis and for the treatment of hy- popigmentary disorders in humans.