R/mpMap: a computational platform for the genetic analysis of multiparent recombinant inbred lines
R/mpMap: a computational platform for the genetic analysis of multiparent recombinant inbred lines
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DOI：
10.1093/bioinformatics/btq719
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发表时间：
2011-03-01
期刊：
影响因子：
5.8
通讯作者：
George, Andrew W.
中科院分区：
文献类型：
--
作者：
Huang, B. Emma;George, Andrew W.
重组自交系的多亲杂交提供了比双亲杂交更高的分辨率来定位标记和数量性状基因座(QTL)的机会。要实现这些交叉的全部潜力，需要能够处理分析中日益增加的统计复杂性的计算工具。R/mpMap提供了一个灵活且可扩展的环境，该环境可以很容易地与其他包对接以满足这一需求。该软件的功能包括模拟、标记图谱构建、单倍型重构和QTL定位。我们通过一个模拟数据示例演示了mpMap的易用特性。
Multiparent crosses of recombinant inbred lines provide opportunity to map markers and quantitative trait loci (QTL) with much greater resolution than is possible in biparental crosses. Realizing the full potential of these crosses requires computational tools capable of handling the increased statistical complexity of the analyses. R/mpMap provides a flexible and extensible environment, which interfaces easily with other packages to satisfy this demand. Functions in the package encompass simulation, marker map construction, haplotype reconstruction and QTL mapping. We demonstrate the easy-to-use features of mpMap through a simulated data example.