Discriminating ability of composite indices for measuring disease activity in rheumatoid arthritis: a comparison of the Chronic Arthritis Systemic Index, Disease Activity Score and Thompson's articular index
Discriminating ability of composite indices for measuring disease activity in rheumatoid arthritis: a comparison of the Chronic Arthritis Systemic Index, Disease Activity Score and Thompson's articular index
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DOI：
10.1093/rheumatology/39.1.90
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发表时间：
2000-01-01
期刊：
影响因子：
5.5
通讯作者：
Ferraccioli, GF
中科院分区：
文献类型：
--
作者：
Salaffi, F;Peroni, M;Ferraccioli, GF
Objective.比较慢性关节炎系统指数（CASI）与疾病活动度评分（DBS）和汤普森关节指数（TAI）对类风湿关节炎（RA）患者疾病活动度高低的鉴别能力。202例RA患者进行了检查。根据先前提出的标准，他们被分为两个亚组：活动性疾病和活动性低的。采用受试者工作特征（ROC）曲线下面积（area under receiver operating characteristic，ROC曲线下面积）评价CASI与DAS、TAI在区分疾病活动性方面的诊断准确性。CASI和TAI的ROC曲线下面积（0.897 +/- 0.023 vs 0.780 +/- 0.032）和DAS和TAI的ROC曲线下面积（0.933 +/- 0.018 vs 0.780 +/- 0.032）之间的差异非常显著（P = 0.0001），从而反映了诊断评估的准确性。CASI与DAS的ROC曲线下面积无差异（曲线下面积差异= 0.036 ± 0.022; P = 0.103）。CASI和DAS一样可以很好地区分高和低疾病活动性。由多个变量组成的索引都比TAI性能更好。我们的结论是，即使包括HAQ，在长期的严重性参数，它是可能的，以构建一个指数，在任何时间点，以及评估疾病的活动。
Objective. To compare the discriminating ability of the chronic arthritis systemic index (CASI), an index that uses the Health Assessment Questionnaire (HAQ) as the main variable, with the disease activity score (DBS) and Thompson's articular index (TAI) to detect high and low disease activity in rheumatoid arthritis (RA).Methods. Two hundred and two RA patients were examined. According to criteria proposed previously, they were divided into two subgroups: these with active disease and those with low activity. The areas under receiver operating characteristic (ROC) curves were employed to assess the diagnostic accuracy of the CASI in comparison with the DAS and TAI for the discrimination of disease activity.Results. The difference between areas under the ROC curves of the CASI and TAI (0.897 +/- 0.023 vs 0.780 +/- 0.032) and between the DAS and TAI (0.933 +/- 0.018 vs 0.780 +/- 0.032) was highly significant (P = 0.0001), thus reflecting the accuracy of the diagnostic assessment. No difference arose between areas under the ROC curves of the CASI and the DAS (difference between areas = 0.036 +/- 0.022; P = 0.103).Conclusion. The CASI discriminates just as well between high and low disease activity as does the DAS. Either index consisting of more than one variable performs better than TAI. We conclude that even including the HAQ, a severity parameter in the long term, it is possible to construct an index that, at any time point, evaluates disease activity as well.