HIV Infection Rates and Risk Behavior among Young Men undergoing community-based Testing in San Diego.
HIV Infection Rates and Risk Behavior among Young Men undergoing community-based Testing in San Diego.
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在圣地亚哥接受社区测试的年轻人的艾滋病毒感染率和风险行为。
DOI：
10.1038/srep25927
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发表时间：
2016-05-16
影响因子：
4.6
通讯作者：
Little SJ
中科院分区：
文献类型：
--
作者：
Hoenigl M;Chaillon A;Morris SR;Little SJ
在美国，大约80%的新艾滋病毒感染发生在男性身上。在被诊断感染艾滋病毒的男子中，五分之四是男男性行为者，年轻男男性行为者（即≤24岁）的比例越来越高。我们对2008年至2014年期间在圣地亚哥参加社区艾滋病毒筛查项目的11，873名顺性别男性进行了回顾性分析，以描述年轻男性的艾滋病毒感染率和性风险行为。在25至49岁的年轻异性恋男子中，艾滋病毒感染率低于异性恋男子（0.3%对1.4%，p = 0.043）。在年轻的男男性行为者中，艾滋病毒流行率为5.5%，每次检测阳性率为3.6%，艾滋病毒发病率为3.4/100人年（95%CI 2.2-5.4）。年轻MSM的每次检测阳性率（p = 0.008）和发病率（p < 0.001）显著高于24岁以上MSM。年轻的男男性接触者诊断为艾滋病毒感染的报告显着更多的血清不一致的无避孕套肛交，细菌性传播感染，甲基苯丙胺和γ-羟基丁酸酯的使用率较高时，与年轻的男男性接触者谁测试阴性。总之，年轻的男男性行为者特别容易感染艾滋病毒，可能是有针对性的预防干预措施，增加检测吸收和/或降低获得艾滋病毒感染的风险的理想候选人。
Approximately 80% of new HIV infections in the United States occur in men. Four out of five men diagnosed with HIV infection are men who have sex with men (MSM), with an increasing proportion of young MSM (i.e. ≤24 years of age). We performed a retrospective analysis 11,873 cisgender men participating in a community based HIV screening program in San Diego between 2008 and 2014 to characterize the HIV prevalence and sexual risk behaviors among young men. In young heterosexual men HIV prevalence was lower compared to heterosexual men between 25 and 49 years of age (0.3% vs. 1.4%, p = 0.043). Among young MSM, HIV prevalence was 5.5%, per test positivity rate 3.6%, and HIV incidence 3.4 per 100 person years (95% CI 2.2–5.4). Per test positivity rate (p = 0.008) and incidence (p < 0.001) were significantly higher among young MSM than among MSM above 24-years of age. Young MSM diagnosed with HIV infection reported significantly more serodiscordant condomless anal intercourse, bacterial sexually transmitted infections, and higher rates of methamphetamine and gamma hydroxybutyrate use when compared to young MSM who tested negative. In conclusion, young MSM are particularly vulnerable to HIV infection and may represent ideal candidates for targeted prevention interventions that increase testing uptake and/or decrease the risk of acquiring HIV infection.