CLONING OF A LEUCINE-ZIPPER PROTEIN RECOGNIZED BY THE SERA OF PATIENTS WITH ANTIBODY-ASSOCIATED PARANEOPLASTIC CEREBELLAR DEGENERATION
CLONING OF A LEUCINE-ZIPPER PROTEIN RECOGNIZED BY THE SERA OF PATIENTS WITH ANTIBODY-ASSOCIATED PARANEOPLASTIC CEREBELLAR DEGENERATION
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DOI：
10.1073/pnas.88.8.3451
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发表时间：
1991-04-01
影响因子：
11.1
通讯作者：
FURNEAUX, HM
中科院分区：
文献类型：
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作者：
FATHALLAHSHAYKH, H;WOLF, S;FURNEAUX, HM
抗体相关的副肿瘤小脑变性（Yo综合征）是一种罕见的疾病，其中免疫反应是专门针对肿瘤组织和小脑。筛选lambda-表达文库，分离出编码这些患者血清识别的主要抗原的cDNA克隆。由cDNA克隆产生的融合蛋白为这种神经系统综合征提供了简单的诊断分析基础。在预测的开放阅读框中出现亮氨酸-拉链和锌指基序，表明该蛋白在基因表达调控中起作用。
Antibody-associated paraneoplastic cerebellar degeneration (the Yo syndrome) is an uncommon disorder in which an immune response is specifically directed against tumor tissue and the cerebellum. Screening of a lambda-expression library has resulted in the isolation of cDNA clones that encode the major antigen recognized by serum from these patients. The fusion protein produced by the cDNA clones provides the basis of a simple diagnostic assay for this neurological syndrome. The occurrence of leucine-zipper and zinc-finger motifs in the predicted open reading frame suggests that this protein plays a role in the regulation of gene expression.