Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear
Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear
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DOI：
10.1101/lm.794808
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发表时间：
2008-04-01
影响因子：
2
通讯作者：
Maren, Stephen
中科院分区：
文献类型：
--
作者：
Ji, Jinzhao;Maren, Stephen
最近的研究表明，灭绝后的特定背景记忆提取需要海马。然而，海马子字段的上下文相关的表达灭绝的贡献是未知的。在本实验中，我们研究了背海马CA 1和CA 3区在灭绝背景特异性中的作用。配对听觉条件刺激（CS）与厌恶性足电击（无条件刺激或US）后，大鼠接受灭绝会议，其中CS没有美国。在实验1中，训练前的神经毒性病变，无论是在CA1或CA3消除的背景依赖性熄灭的恐惧。实验2中，在消退训练后对CA 1或CA 3进行损伤。在这种情况下，只有CA1病变损害了灭绝的上下文依赖性。总的来说，这些结果表明，海马区CA1和CA3有助于收购的上下文相关的灭绝，但只有CA1区是需要上下文记忆检索。
Recent studies demonstrate that context-specific memory retrieval after extinction requires the hippocampus. However, the contribution of hippocampal subfields to the context-dependent expression of extinction is not known. In the present experiments, we examined the roles of areas CA1 and CA3 of the dorsal hippocampus in the context specificity of extinction. After pairing an auditory conditional stimulus (CS) with an aversive footshock (unconditional stimulus or US), rats received extinction sessions in which the CS was presented without the US. In Experiment 1, pretraining neurotoxic lesions in either CA1 or CA3 eliminated the context dependence of extinguished fear. In Experiment 2, lesions of CA1 or CA3 were made after extinction training. In this case, only CA1 lesions impaired the context dependence of extinction. Collectively, these results reveal that both hippocampal areas CA1 and CA3 contribute to the acquisition of context-dependent extinction, but that only area CA1 is required for contextual memory retrieval.