The composition of the ceramides from human stratum corneum and from comedones.
The composition of the ceramides from human stratum corneum and from comedones.
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来自人类角质层和粉刺的神经酰胺的成分。
DOI：
10.1111/1523-1747.ep12265510
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Downing,DT
中科院分区：
文献类型：
--
作者：
Wertz,PW;Miethke,MC;Long,SA;Strauss,JS;Downing,DT
用乙醇洗涤法收集人表皮表面脂类，用薄层层析-光密度法对神经酰胺进行定量。分离得到6个神经酰胺组分，并对每个组分的结构组成进行了详细分析。最不寻常的表皮神经酰胺含有鞘氨醇碱基和酯连接的非羟基酸，其中41%是亚油酸。粉刺酮类神经酰胺中亚油酸的含量为6%。这支持了毛囊上皮局部亚油酸不足是粉刺发生的病因学因素的假设。
Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon ω-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.