MECHANISMS OF ACTION OF ANTI-TUMOUR POLYSACCHARIDES .1. EFFECTS OF ANTILYMPHOCYTE SERUM ON ANTI-TUMOUR ACTIVITY OF LENTINAN
MECHANISMS OF ACTION OF ANTI-TUMOUR POLYSACCHARIDES .1. EFFECTS OF ANTILYMPHOCYTE SERUM ON ANTI-TUMOUR ACTIVITY OF LENTINAN
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DOI：
10.1002/ijc.2910080106
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发表时间：
1971-01-01
影响因子：
6.4
通讯作者：
CHIHARA, G
中科院分区：
文献类型：
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作者：
MAEDA, YY;HAMURO, J;CHIHARA, G
研究了香菇多糖（一种抗肿瘤多糖）引起的小鼠移植肿瘤消退的机制。1)当动物在肿瘤接种前12天开始接受预处理时，香菇多糖显示出显著的抗肿瘤作用。2)从肿瘤移植后24小时起，注射抗淋巴细胞血清可阻断香菇多糖的抗肿瘤作用。由该血清攻击的类肉瘤细胞显然在香菇多糖诱导的肿瘤消退中起重要作用。3)考虑到抗淋巴细胞血清作为免疫抑制剂的选择性作用，香菇多糖抗肿瘤作用的机制之一可能是刺激细胞介导的反应。4)针对香菇多糖的体液抗体似乎不参与肿瘤消退。
Mechanisms of the regression of transplantated tumours in mice caused by lentinan, an anti‐tumour polysaccharide, were examined. 1) Lentinan showed a marked anti‐tumour effect when the animal was pretreated, starting 12 days before tumour inoculation. 2) The anti‐tumour effect of lentinan was blocked by injection of anti‐lymphocyte serum from 24 h after tumour transplantation. Lymphoid cells attacked by this serum apparently play an important role in tumour regression induced by lentinan. 3) Considering the selective actions of anti‐lymphocyte serum as an immunosuppressor, one of the mechanisms responsible for the anti‐tumour effect of lentinan may be the stimulation of cell‐mediated responses. 4) Humoral antibodies against lentinan do not seem to participate in tumour regression.