New alkaloids of the sarpagine group from Rauvolfia serpentina hairy root culture
New alkaloids of the sarpagine group from Rauvolfia serpentina hairy root culture
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DOI：
10.1021/np0200919
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发表时间：
2002-07-01
影响因子：
5.1
通讯作者：
Stöckigt, J
中科院分区：
文献类型：
--
作者：
Sheludko, Y;Gerasimenko, I;Stöckigt, J
从毛状根培养物中分离出三种新的单萜吲哚生物碱：19(S),20(R)-二氢peraksine (1)、19(S),20(R)-二氢peraksine-17-al (2)和10-羟基-19(S),20(R)-二氢peraksine (3)以及16种已知的生物碱4-19 Rauvolfia serpentina 的结构，通过 1D 和 2D NMR 分析阐明了它们的结构。考虑到新生物碱的立体化学和初步酶学研究的结果，讨论了新生物碱之间假定的生物合成关系。
Three new monoterpenoid indole alkaloids, 19(S),20(R)-dihydroperaksine (1), 19(S),20(R)-dihydroperaksine-17-al (2), and 10-hydroxy-19(S),20(R)-dihydroperaksine (3), along with 16 known alkaloids 4-19 were isolated from hairy root culture of Rauvolfia serpentina, and their structures were elucidated by 1D and 2D NMR analyses. Taking into account the stereochemistry of the new alkaloids and results of preliminary enzymatical studies, the putative biosynthetical relationships between the novel alkaloids are discussed.