First-in-human pilot study of a spatial frequency domain oxygenation imaging system
First-in-human pilot study of a spatial frequency domain oxygenation imaging system
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DOI：
10.1117/1.3614566
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发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Frangioni, John V.
中科院分区：
文献类型：
--
作者：
Gioux, Sylvain;Mazhar, Amaan;Frangioni, John V.
氧合测量广泛用于患者护理。然而，目前大多数临床可用的仪器由接触式探头组成，仅提供对患者的全局监测（例如，脉搏血氧饱和度探头）或小区域的局部监测（例如，基于光谱的探头）。在不事先了解缺陷位置的情况下，大面积组织的氧合可视化有可能改善许多外科和重症监护应用中的患者管理。在这项研究中，我们提出了一种临床兼容的多光谱空间频域成像（SFDI）系统，该系统针对手术氧合成像进行了优化。该系统用于对大面积 (16x12 cm) 的组织氧合进行成像，并在临床前研究期间通过比较 FDA 批准的临床氧合探针获得的结果进行了验证。在约克夏猪上进行了皮瓣、肠和肝血管闭塞实验，结果表明，在实验过程中，使用 SFDI 测量的氧饱和度相对变化的准确度与使用 FDA 批准的设备测量的氧饱和度相对变化的准确度在 10% 以内。最后，新的 SFDI 系统在一项首次人体试点研究中被转化为临床，该研究对乳房重建手术期间的皮瓣氧合进行成像。总的来说，这项研究为使用 SFDI 进行内源性对比成像的临床转化奠定了基础。 02011 学会或光电仪器工程师协会 (SPIE)。 [DOI：10.1117/1.3614566]
Oxygenation measurements are widely used in patient care. However, most clinically available instruments currently consist of contact probes that only provide global monitoring of the patient (e.g., pulse oximetry probes) or local monitoring of small areas (e.g., spectroscopy-based probes). Visualization of oxygenation over large areas of tissue, without a priori knowledge of the location of defects, has the potential to improve patient management in many surgical and critical care applications. In this study, we present a clinically compatible multispectral spatial frequency domain imaging (SFDI) system optimized for surgical oxygenation imaging. This system was used to image tissue oxygenation over a large area (16x12 cm) and was validated during preclinical studies by comparing results obtained with an FDA-approved clinical oxygenation probe. Skin flap, bowel, and liver vascular occlusion experiments were performed on Yorkshire pigs and demonstrated that over the course of the experiment, relative changes in oxygen saturation measured using SFDI had an accuracy within 10% of those made using the FDA-approved device. Finally, the new SFDI system was translated to the clinic in a first-in-human pilot study that imaged skin flap oxygenation during reconstructive breast surgery. Overall, this study lays the foundation for clinical translation of endogenous contrast imaging using SFDI. 02011 Society or Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3614566]