How to recognize inborn errors of immunity in a child presenting with a malignancy: guidelines for the pediatric hemato-oncologist.
How to recognize inborn errors of immunity in a child presenting with a malignancy: guidelines for the pediatric hemato-oncologist.
复制标题
如何识别患有恶性肿瘤的儿童的先天性免疫缺陷：儿科血液肿瘤学家指南。
DOI：
10.1080/08880018.2022.2085830
复制
发表时间：
2023
影响因子：
1.7
通讯作者：
Bosch JVWT
中科院分区：
文献类型：
--
作者：
Bosch JVWT
先天性免疫错误（IEI）是一组由免疫系统遗传缺陷引起的疾病，可导致感染、自身免疫、自身炎症和恶性肿瘤风险增加。在某些情况下，恶性肿瘤可能是潜在的IEI的第一个征兆。由于这些患者的治疗策略可能不同，儿科血液肿瘤学家认识到潜在的IEI是很重要的。本文由儿科免疫学、血液肿瘤学、病理学和遗传学专家撰写，旨在为儿科血液肿瘤学家提供关于如何识别可能的潜在IEI以及可以进行哪些诊断测试的指南，并给出一些治疗可能性的考虑。
Inborn errors of immunity (IEI) are a group of disorders caused by genetically determined defects in the immune system, leading to infections, autoimmunity, autoinflammation and an increased risk of malignancy. In some cases, a malignancy might be the first sign of an underlying IEI. As therapeutic strategies might be different in these patients, recognition of the underlying IEI by the pediatric hemato-oncologist is important. This article, written by a group of experts in pediatric immunology, hemato-oncology, pathology and genetics, aims to provide guidelines for pediatric hemato-oncologists on how to recognize a possible underlying IEI and what diagnostic tests can be performed, and gives some consideration to treatment possibilities.