The TRPV4 Channel
The TRPV4 Channel
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DOI：
10.1007/978-3-642-54215-2_12
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Valverde, Miguel A.
中科院分区：
文献类型：
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作者：
Garcia-Elias, Anna;Mrkonjic, Sanela;Valverde, Miguel A.
广泛分布的TRPV4阳离子通道参与物理（渗透、机械和热）和化学（内源性、植物衍生和合成配体）刺激的转导。在这一章中，我们将审查TRPV4的表达，生物物理学，结构，调节，和相互作用的合作伙伴，以及生理和病理的见解TRPV4动物模型和人类遗传研究。
The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.