Chromosome studies in human in vitro fertilization
Chromosome studies in human in vitro fertilization
复制标题
人类体外受精的染色体研究
DOI：
10.1007/bf00290960
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发表时间：
1986
期刊：
影响因子：
5.3
通讯作者：
R. Aitken
中科院分区：
文献类型：
--
作者：
R. Angell;A. Templeton;R. Aitken
摘要研究了来自供体精子体外受精的供体卵母细胞的 22 个人类植入前胚胎的染色体组成，以评估致命染色体异常对不孕妇女胚胎移植后体外受精胚胎植入高失败率的影响。发现了不分离的证据，导致三体性、单体性和零体性；结构异常；单倍体；和三倍体。尽管其染色体互补体具有致命性，但这些胚胎在形态上无法与具有正常染色体的胚胎区分开来。
SummaryThe chromosome constitution of 22 human preimplantation embryos from donor oocytes fertilized in vitro by donor sperm was studied to assess the contribution of lethal chromosome anomalies to the high failure rate of implantation of in vitro fertilized embryos after embryo transfer in infertile women. Evidence was found of nondisjunction, resulting in trisomy, monosomy, and nullosomy; structural abnormalities; haploidy; and triploidy. Despite the lethality of their chromosome complements, these embryos could not be distinguished morphologically from those with normal chromosomes.