Quantitative genetics of serum sex hormone-binding globulin levels in participants in the San Antonio Family Heart Study.
Quantitative genetics of serum sex hormone-binding globulin levels in participants in the San Antonio Family Heart Study.
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圣安东尼奥家庭心脏研究参与者血清性激素结合球蛋白水平的定量遗传学。
DOI：
10.1016/s0026-0495(97)90266-3
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
MacCluer,JW
中科院分区：
文献类型：
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作者：
Jaquish,CE;Blangero,J;Haffner,SM;Stern,MP;MacCluer,JW
性激素结合球蛋白 (SHBG) 是一种类固醇结合血浆蛋白，与睾酮具有高亲和力，在许多人群中，睾酮与心血管疾病风险呈负相关。 SHBG 也可能在某些组织中充当受体。尽管人们对性激素结合球蛋白 (SHBG) 的功能了解相对较多，但对于导致血清性激素结合球蛋白 (SHBG) 水平正常变化的遗传因素知之甚少。我们估计了参与圣安东尼奥家庭心脏研究 (SAFHS) 的 717 名相关墨西哥裔美国人的血清 SHBG 水平的遗传力 (h2)。我们发现血清 SHBG 水平具有显着的遗传力（h2= 0.31，P < .0001）；年龄、外源性激素、吸烟状况、糖尿病状况和肥胖与 SHBG 平均水平显着相关 (P < .05)。性别与平均 SHBG 水平相关，但与 SHBG 水平的遗传或环境差异无关；男性和女性的遗传力估计相同。这些结果表明，墨西哥裔美国人的性激素结合球蛋白 (SHBG) 受到显着的遗传影响。因此，SHBG 可能被证明是该人群以及其他人群心血管疾病遗传风险的重要指标。
Sex hormone—binding globulin (SHBG) is a steroid-binding plasma protein with a high affinity for testosterone that has been inversely associated with cardiovascular disease risk in many populations. SHBG may also act as a receptor in some tissues. Although the function of SHBG is relatively well understood, comparatively little is known about genetic factors contributing to the normal variation of serum SHBG levels. We estimated the heritability (h2) of serum SHBG levels in 717 related Mexican-Americans participating in the San Antonio Family Heart Study (SAFHS). We found a significant heritability (h2= 0.31, P < .0001) for serum SHBG levels; age, exogenous hormones, smoking status, diabetic status, and adiposity showed significant associations (P < .05) with mean levels of SHBG. Sex was associated with mean SHBG levels but not with genetic or environmental variance in SHBG levels; heritability estimates were the same for males and females. These results indicate a significant genetic influence on SHBG in Mexican-Americans. Thus, SHBG may prove to be an important indicator of genetic risk for cardiovascular disease in this population, as well as others.