Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization
Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization
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无溶剂加氢异构化高选择性合成顺式2,2,4,4-四甲基环丁烷-1,3-二醇
DOI：
10.1002/ajoc.202200263
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hironao Sajiki
中科院分区：
文献类型：
--
作者：
Kwihwan Park;Shinichi Furusato;Chikara Furugen;Takashi Ikawa;Tsuyoshi Yamada;Hironao Sajiki
本研究在无溶剂条件下，利用碳上钌催化CBDK加氢生产顺式CBDO。使用钌催化剂和氢气的异构化可以提高顺式CBDO的选择性形成。此外，基于密度泛函理论（DFT）的计算，提出了反应机理——力选择性。
In this study, ruthenium‐on‐carbon‐catalyzed hydrogenation of CBDK was developed for the production ofcis‐CBDO under solvent‐free conditions. Isomerization using a ruthenium catalyst and hydrogen gas may improve the selective formation ofcis‐CBDO. Moreover, the reaction mechanisms forcis‐selectivity was proposed based on density functional theory (DFT) calculations.